A clinical trial to compare and study the effects of delayed sequence intubation versus rapid sequence intubation in critically ill patients requiring endotracheal intubation.

Evaluation of safety and efficacy of delayed sequence intubation as compared to rapid sequence intubation in critically ill patients requiring endotracheal intubation A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074483

Enrollment

Registered

2024-09-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: Delayed sequence intubation: Critically ill patients requiring endotracheal intubation, performed delayed sequence intubation where this technique starts with sedation by giving ketamin

Eligibility

Inclusion criteria

Inclusion criteria: All patients requiring intubation in the emergency department.

Exclusion criteria

Exclusion criteria: 1. Age less than 14 years. 2. Pregnant patients. 3. Patients intubated before enrolment. 4. Patient with tracheostomy. 5. Patient in cardiac arrest. 6. The patient planned for endotracheal intubation by any technique other than tracheal intubation by either direct laryngoscopy or video laryngoscopy as the initial attempt. 7. Patient requiring urgent intubation as determined by the treating clinician precluding time for randomisation. 8. oxygen saturation is not recordable on the finger pulse-oximetry probe.

Design outcomes

Primary

Measure	Time frame
1. To compare the proportion of peri-intubation hypoxia in patients undergoing Delayed sequence intubation when compared to patients undergoing Rapid sequence intubation during emergency endotracheal intubation. 2. To compare the risk of peri-intubation aspiration in patients undergoing Delayed sequence intubation to patients undergoing Rapid sequence intubation during emergency endotracheal intubation.Timepoint: After 15 minutes of placement of the endotracheal tube.	—

Measure

Time frame

1. To compare the proportion of peri-intubation hypoxia in patients undergoing Delayed sequence intubation when compared to patients undergoing Rapid sequence intubation during emergency endotracheal intubation. 2. To compare the risk of peri-intubation aspiration in patients undergoing Delayed sequence intubation to patients undergoing Rapid sequence intubation during emergency endotracheal intubation.Timepoint: After 15 minutes of placement of the endotracheal tube.

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Secondary

Measure	Time frame
1. To determine the effect of delayed sequence intubation compared to Rapid sequence intubation on the first pass success rate. 2. To determine the peri- intubation adverse events (cardiac arrest, peri- intubation hypotension, arrhythmia) during delayed sequence intubation compared to rapid sequence intubation. 3• To study the mortality difference up to discharge or a period of 7 days in patients undergoing DSI when compared to patients undergoing RSI. Timepoint: 1. After 15 minutes of placement of the endotracheal tube. 2. After 15 minutes of placement of the endotracheal tube. 3. Maximum of 7 days on arrival to emergency.	—

Measure

Time frame

1. To determine the effect of delayed sequence intubation compared to Rapid sequence intubation on the first pass success rate. 2. To determine the peri- intubation adverse events (cardiac arrest, peri- intubation hypotension, arrhythmia) during delayed sequence intubation compared to rapid sequence intubation. 3• To study the mortality difference up to discharge or a period of 7 days in patients undergoing DSI when compared to patients undergoing RSI. Timepoint: 1. After 15 minutes of placement of the endotracheal tube. 2. After 15 minutes of placement of the endotracheal tube. 3. Maximum of 7 days on arrival to emergency.

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Countries

India

Contacts

Public ContactDr Basavaraj K

AIIMS New Delhi

akshay2111@gmail.com9654015399

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026