Health Condition 1: I130- Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
Conditions
Interventions
Intervention1: High dose Nitroglycerine: Patients presenting to ED with acute pulmonary edema will undergo High dose Nitroglycerine(100mcg/min)stat infusion via intravenous route for 1 hour
Control I
Sponsors
Austin Pauly N
Eligibility
Inclusion criteria
Inclusion criteria: above 18 years respiratory rate above 30cycles per minute Spo2 less than 90 in room air Coarse crepitations on auscultation B profile on Point of care lung ultrasound Elevated systolic blood pressure above 180 mmHg
Exclusion criteria
Exclusion criteria: Pregnant patients Aortic dissection Eclampsia intracranial hemorrhage Patients already on non NTG vasoactive medications Nitroglycerine allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the reduction of Mean arterial pressure in 1 hour with low dose vs high dose nitroglycerine in patients presenting to the emergency department with acute pulmonary edema.Timepoint: 5 minutes assessment of blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the frequency of endotracheal intubation between the two groups. To compare the mortality between the two groups. To compare the complications of nitroglycerine between the two groups.Timepoint: 1 hour,48 hours,1 week or at the time of discharge at the earliest. | — |
Countries
India
Contacts
Public ContactMadhu Srinivasarangan
JSS Medical college and Hospital, JSS AHER
Outcome results
None listed