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Comparison of effect of different doses of intrathecal dexmedetomidine with levobupivacaine on duration of analgesia in patients undergoing lower limb surgeries.

To Compare The Effect Of Different Doses Of Intrathecal Dexmedetomidine As An Adjuvant To Hyperbaric Levobupivacaine On Duration Of Analgesia In Lower Limb Surgeries - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/074456
Enrollment
75
Registered
2024-09-26
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Spinal anaesthesia block: Comparison of different doses of intrathecal dexmedetomidine and hyperbaric levobupivacaine on duration of analgesia, hemodynamic parameters and motor and sen

Sponsors

Adesh Institute of medical sciences and research Bathinda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I,II Weight between 50-90 kgs Surgeries under spinal anesthesia in lower limb Height more than 150 cm

Exclusion criteria

Exclusion criteria: Patients refusing for Spinal Anaesthesia Patients with coagulopathy, severe anaemia or patients on anticoagulant therapy Patient with uncontrolled coexisting systemic or metabolic disease Patients with history of labile hypertension, heart blocks (heart rate less than 50/min), dysarrhythmias. Patients on a2 adrenergic agonists and beta blockers. History of hypersensitivity reaction to local anaesthetic drug or adjuvant drug (levobupivacaine or dexmedetomidine) Patient having neurological disorder and psychiatric disorder. Patient with spine tumors, spine deformity and spinal trauma Pregnant patient Patient having risk of developing sepsis and bacterial wound infection at the site of spinal injection.

Design outcomes

Primary

MeasureTime frame
To compare the efficacy and safety of different doses of intrathecal dexmedetomidine as an adjuvant to hyperbaric levobupivacaine for duration of effective analgesia in lower limb surgeries. Timepoint: Duration of analgesia will be taken as time from administration of subarachnoid injection to patients complaint of pain at surgical site with VAS score more than 3—

Secondary

MeasureTime frame
To assess haemodynamics in perioperative period.( heart rate, respiratory rate, blood pressure, oxygen saturation)Timepoint: T0- 3min T1-6min T2- 9min T3- 12min T4-15min T5-30 min T6-45min T7-60 min T8-75 min T9-90 min T10-105 min T11-120 min T12-135 min T13-150 min T14-165 min T15-180 min T16-195 min T17- 210 min T18- 225 min;To compare onset, duration and recovery of sensory and motor nerve blockade in all 3 groups. Timepoint: T0- 15min T1- 30 min T2-45 min T3-60 min;To monitor and treat the complications in perioperative period if any.Timepoint: during perioperative period—

Countries

India

Contacts

Public ContactDr Aakanksha

Adesh Institute of Medical sciences and Research(AIMSR), Bathinda

bansalshilpa304@gmail.com9915433522

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026