Effect of raising and lowering blood pressure procedure on kidney complications in patients with Diabetes mellitus

Effect of Remote Ischemic conditioning on albuminuria in adults with Diabetes mellitus (RICADIME): A Parallel group, double blind, Sham controlled, Randomized clinical trial - RICADIME

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074453

Enrollment

Registered

2024-09-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E112- Type 2 diabetes mellitus with kidney complications

Interventions

Intervention1: Remote Ischemic conditioning: Remote Ischemic conditioning (RIC) will be induced using a digital automatic pneumatic tourniquet device. The device will be applied on the healthy upper l

Eligibility

Inclusion criteria

Inclusion criteria: patients with type-2 Diabetes mellitus with moderate and severely increased albuminuria

Exclusion criteria

Exclusion criteria: Hypertension Peripheral vascular disease of upper limbs Arteriovenous fistula and arteriovenous graft in upper limb eGFR less than 45 ml/mi/1.73 m2 Kidney transplant and renal disease requiring dialysis Pregnancy patients on ACE inhibitors angiotensin receptor blockers calcium channel blocker beta blockers Congestive heart failure chronic liver disease Malignancy UTI

Design outcomes

Primary

Measure	Time frame
Primary outcome will be reduction in urinary ACR Timepoint: Eight weeks	—

Secondary

Measure	Time frame
Change in HbA1c Change in Serum creatinine Change in eGFRTimepoint: Eight weeks	—

Countries

India

Contacts

Public ContactNishanth Dev

Department of Medicine

devnishant@gmail.com01126730356

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026