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A study comparing two methods of nerve treatment for managing cancer pain in the upper abdomen.

Comparison of cooled versus conventional radiofrequency ablation of thoracic splanchnic nerves for the management of cancer pain: A prospective exploratory randomized controlled study. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/074384
Enrollment
60
Registered
2024-09-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C169- Malignant neoplasm of stomach, unspecified Health Condition 2: C179- Malignant neoplasm of small intestine, unspecified Health Condition 3: C188- Malignant neoplasm of overlappingsites of colon Health Condition 4: C229- Malignant neoplasm of liver, not specified as primary or secondary Health Condition 5: C23- Malignant neoplasm of gallbladder Health Condition 6: C259- Malignant neoplasm of pancreas, unspecified Health Condition 7: C649- Malignant neoplasm of unspecifie

Interventions

Intervention1: Cooled radiofrequency ablation: Cooled radiofrequency ablation of bilateral thoracic splanchnic nerves at the T10 and T11 levels using a 4 mm active tip radiofrequency probe, administer

Sponsors

Karthik Pandian M
Lead Sponsor
All India Institute of Medical Sciences Rishikesh
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age: 18-70 years. 2) Patients of both sexes who have experienced upper abdominal pain (visceral pain with NRS greater than 4) for a duration of more than 3 months. 3) Patients who were taking the maximum tolerable dose of opioids.�  4) Splanchnic nerve accessible for bilateral neurolysis.

Exclusion criteria

Exclusion criteria: 1. Patient refusal, 2. Organ failure, 3. Coagulation disorders, 4. Local infection at the puncture site, 5. Sepsis, 6. Allergy to the contrast dye, 7. Pregnant women, 8. Psychiatric illness that affects cooperation

Design outcomes

Secondary

MeasureTime frame
Change in sleep score (PSQI-The Pittsburgh Sleep Quality Index)Timepoint: Baseline, 1 week, 1 month, and 3 months post-intervention;Change in analgesic requirement (medication quantification scale)Timepoint: Baseline to 3 months post-intervention;To assess the complications of the interventionTimepoint: 3 months—

Primary

MeasureTime frame
Change in pain NRS(numeric rating scale) score at restTimepoint: Baseline, 1 week, 1 month, and 3 months post-intervention—

Countries

India

Contacts

Public ContactKarthik Pandian

All India Institute of Medical Sciences, Rishikesh

ajitdr.ajit@gmail.com9910789377

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 27, 2026