New toothpaste containing an anti-microbial agent to combat tooth decay during orthodontic treatment

Synthesis of a novel dentifrice containing 4-HCA and assessing its effect in preventing white spot lesions in patients undergoing orthodontic treatment - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074319

Enrollment

Registered

2024-09-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: 0.2% 4-HCA: 0.2% w/w of 4-hydroxycinnamic acid in the dentifrice. Pea sized amount of dentifrice to be used while brushing every day twice (once in the morning and once at night) for 3

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing orthodontic treatment with fixed appliance

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
White spot lesions assessment using- Photographic analysis of teeth ICDAS scoring DIAGNOdent Periodontal outcomes- Plaque index Bacterial counts using Real-time Polymerase Chain Reaction (RT-PCR)Timepoint: Baseline and at 6 months	—

Secondary

Measure	Time frame
Periodontal outcomes- Plaque index Bacterial counts using Real-time Polymerase Chain Reaction (RT-PCR)Timepoint: Baseline and 6 momths	—

Countries

India

Contacts

Public ContactRavindra Kumar Jain

Saveetha Dental College and Hospital

ravindrakumar@saveetha.com9884729660

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026