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Exploring the link between Fibroblast Growth factor (FGF-23) and kidney disease progression in chronic kidney disease

Association of fibroblast growth factor (FGF-23) and metabolomic profile with cardiorenal outcomes in patients with chronic kidney disease: A Prospective Observational study - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/09/074274
Enrollment
250
Registered
2024-09-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N182- Chronic kidney disease, stage 2 (mild) Health Condition 2: N183- Chronic kidney disease, stage 3 (moderate) Health Condition 3: N184- Chronic kidney disease, stage 4 (severe)

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Manipal Academy of Higher Education
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The study at Kasturba Hospital, Manipal, will include adult CKD patients stages 2-4 aged 18 and above with an estimated GFR of 25-75 mL/min/1.73m²

Exclusion criteria

Exclusion criteria: History of atherosclerotic cardiovascular disease, pregnancy, renal transplant, polycystic kidney disease, renal cancer, chemotherapy or immunosuppressive therapy, HIV, myeloma, cirrhosis, or active infection

Design outcomes

Primary

MeasureTime frame
Rapid progression in CKDTimepoint: 1 Year

Secondary

MeasureTime frame
metabolomic profiling with rapid progressionTimepoint: 1 Year;longitudinal trajectory with rapid progressionTimepoint: 1 Year;Major adverse cardiovascular eventsTimepoint: 0,6,12,18,24(Every six months);All-cause MortalityTimepoint: 0,6,12,18,24(Every six months);ProtienuriaTimepoint: 0,6,12,18,24(Every six months)

Countries

India

Contacts

Public ContactDr Indu Ramachandra Rao

Kasturba Medical College

chandrakar.kmcmpl2023@learner.manipal.edu7000493133

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026