Health Condition 1: J969- Respiratory failure, unspecified
Conditions
Interventions
Intervention1: Group A: The patients in Group A will receive aminophylline infusion of 200 mg over one hour, twice a day (Equivalent dose of 320 mg theophylline per day)[1] for 5 days.
Control Interve
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All patients in the age group of 18-75 years admitted in AIIMS ICU with an anticipated duration of mechanical ventilation more than 72 hours will be enrolled in the study. The enrollment will be carried out within 24 hours of onset of mechanical ventilation.
Exclusion criteria
Exclusion criteria: 1. Pre-existing muscular disease 2. Phrenic nerve lesions/ Diaphragmatic palsy 3. Post-Thoracotomy or any Diaphragmatic surgery 4. Pregnant Women 5. Pneumothorax/ Pneumomediastinum 6. Intra-abdominal hypertension 7. Uncontrolled arrythmia, seizures or hyperthyroidism 8. Patients on continuous infusion of Neuromuscular blocking drugs 9. Previous theophylline use. 10. Inability to visualize diaphragm on ultrasound 11. Refusal of consent to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The goal of this study is to find out the change in diaphragmatic excursion on day 5 with respect to baseline, with the use of low dose aminophylline for 5 days.Timepoint: Day 1, Day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Diaphragmatic thickening fraction on day 3 and day 5 with respect to baseline.Timepoint: Day 1, Day 3, Day 5;Change in Intercostal muscle contractility with respect to baseline parasternal intercostal muscle thickening fraction (PMTF)Timepoint: Day 1, Day 5;Change in Maximum inspiratory pressureTimepoint: Day 1, Day 5;Change in RSBI (Rapid Shallow Breathing Index)Timepoint: Day 1, Day 5;Length of ICU stayTimepoint: Day 1 to Day of shifting from ICU;Success with SBT (Spontaneous breathing trial)Timepoint: Day 1 to Day of Extubation;Weaning time and Duration of mechanical ventilationTimepoint: Day 1 to Day of Extubation | — |
Countries
India
Contacts
Public ContactDr Bikash Ranjan Ray
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed