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To study colistin resistance in Gram-negative bacteria by performing various phenotypic and genotypic methods

Phenotypic Detection and Genotypic Characterization of colistin resistance in Gram-negative bacilli - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/09/074195
Enrollment
200
Registered
2024-09-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: NIL: NIL

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Gram-negative bacilli isolated and stocked from any clinical sample routinely submitted for a bacterial culture that tests resistance to colistin by broth microdilution method as well as carbapenem-resistance gram-negative bacteria.

Exclusion criteria

Exclusion criteria: Gram-negative bacilli with intrinsic resistance to colistin.

Design outcomes

Primary

MeasureTime frame
1. To detect the presence of the mcr-1 gene and its variants in Gram-Negative Bacilli which may lead to low/high-level colistin resistance. 2. To evaluate various phenotypic tests for determining colistin resistance in comparison to Broth MicrodilutionTimepoint: 3 YEARS—

Secondary

MeasureTime frame
1. To determine susceptibility to currently available and newer treatment options as alternatives to colistin 2. To determine genes encoding for Carbapenemase and Extended-Spectrum Beta-Lactamase (ESBLs)Timepoint: 3 YEARS—

Countries

India

Contacts

Public ContactDr Sonal Saxena

Maulana Azad Medical College

sonalsaxena3@gmail.com9811349053

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026