Health Condition 1: D332- Benign neoplasm of brain, unspecified
Conditions
Interventions
Sponsors
National Institute of Mental health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: All adult consenting patients undergoing elective tumour resection surgeries and spinal cord surgeries
Exclusion criteria
Exclusion criteria: Patients below 18 years of age, refusal of consent, awake and emergency surgeries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to compare the preoperative (pre surgical incision) and postoperative (at 24 hours postoperative) neuroinflammatory markers in elective brain and spine surgeriesTimepoint: Preoperative (pre surgical incision) and postoperative (at 24 hours postoperative) neuroinflammatory markers [IL-33, Neurofilament light chain (Nf-L) and MMP 9] in elective brain and spine surgeries | — |
Secondary
| Measure | Time frame |
|---|---|
| correlation between pre-post change in neuroinflammatory markers and incidence of post-opertaive delirium (POD), Delayed cognitive neurocognitive recovery (DCNR), and postoperative neurocognitive dysfunction (PND) at 6 months after cranial and spinal surgeries.Timepoint: Montreal Cognitive Assessment (MOCA) (Annexure-1) will be used to assess baseline neurocognitive disorder (NCD) and POD between the 2nd -3rd, and 5th -7th postoperative day or at the time of discharge, whichever is earlier.;to study the relationship between pain, inflammation and PODTimepoint: Assessment of pain using the Visual Analogue Scale (VAS) score will be done in the pre-operative period and between the 2nd -3rd, and 5th -7th postoperative day or at the time of discharge, whichever is earlier.;to study the relationship between sleep, inflammation and PODTimepoint: Assessment of sleep quality using the Richard Campbell sleep questionnaire (RCBSQ) will be done in the pre-operative period and between the 2nd -3rd, and 5th -7th postoperative day or at the time of discharge, whichever is earlier | — |
Countries
India
Contacts
Public ContactSangeetha RP
National Institute of Mental Health and Neurosciences
Outcome results
None listed