A study to determine whether dexamethasone and 2 percent lignocaine can be used as an alternative to air for endotracheal tube cuff inflation so that post operative sore throat, cough, and other morbidities be reduced.

A study to compare the effects on laryngotracheal morbidity of air, 2 percent alkalinized lignocaine and dexamethasone used for endotracheal tube cuff inflation, a randomized control trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074162

Enrollment

165

Registered

2024-09-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 2% Alkalinized lignocaine, : 2% lignocaine + sodium bicarbonate 7.5% (9ml + 1ml), this will be made into a stock solution of 10 ml. Around 4-6 ml will be used for inflating the endotrac

Eligibility

Inclusion criteria

Inclusion criteria: age 18 to 60 years, ASA 1 and 2 undergoing elective surgery under general anaesthesia, patient given written informed consent.

Exclusion criteria

Exclusion criteria: Duration of surgery 2 to 4 hrs, difficult airway requiring more than 2 trials of intubation, history of sore throat, allergies, bronchial asthma, chronic obstructive pulmonary disease, upper respiratory tract infections.

Design outcomes

Primary

Measure	Time frame
sore throat incidence/severityTimepoint: 1 hr,12 hr,24 hr post extubation	—

Secondary

Measure	Time frame
coughTimepoint: 1 hr,12 hr,24 hr post extubation;dysphagiaTimepoint: 1 hr,12 hr,24 hr post extubation;hoarseness of voiceTimepoint: 1 hr,12 hr,24 hr post extubation;PONVTimepoint: 1 hr,12 hr,24 hr post extubation	—

Countries

India

Contacts

Public ContactSubhrajyoti Das

Institute of Postgraduate Medical Education and Research

blowfans@yahoo.co.in09830148042

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026