Health Condition 1: K918- Other intraoperative and postprocedural complications and disorders of digestive system
Conditions
Interventions
Intervention1: Ondansetrone: It is a selective 5-HT3 serotonin-receptor antagonist used for its antiemetic properties. It is one of the four FDA-approved 5-HT3 serotonin-receptor antagonists used to c
Sponsors
Dr Hari Govindh A
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing general anesthesia with endotracheal intubation for laproscopic surgeries
Exclusion criteria
Exclusion criteria: 1.Patients having allergies to the drug. 2.Transplant surgery or any surgery where postoperative emesis could pose a significant danger to the patient. 3.Had received Amisulpride for any indication in the 2 weeks before screening. 4. H/O vestibular disease or dizziness, were receiving regular anti-emetic therapy, still going on within 1 week before surgery, had a known prolactin-dependent tumor or Pheochromocytoma. 5. Pregnant or breastfeeding. 6.Clinically significant cardiac arrhythmia or congenital QT syndrome, had a h/o epilepsy or Parkinson’s disease or were being treated with levodopa.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare two drugs intraoperatively to see the effect of post op nausea and vomitingTimepoint: 15min 30min 45min 60min 1.30hour 2.00hour 2.30hour 3.00hour 6th hour 12th hour 18th hour 24th hour | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare between Amisulpride and Ondansetron for prevention of postoperative nausea and vomiting in laparoscopic surgery. To determine any complications in study drugs Amisulpride and Ondansetron. Timepoint: 15min 30min 45min 60min 1.30hour 2.00hour 2.30hour 3.00hour 6th hour 12th hour 18th hour 24th hour | — |
Countries
India
Contacts
Public ContactDr. Sowmya MJ
RajaRajeswari Medical College and Hospital
Outcome results
None listed