Evaluation of blood clotting ability of frozen platelets in trauma patients against the standard platelet transfusion

Hemostatic evaluation of cryopreserved platelets concentrates compared to the room temperature stored platelet concentrates in trauma patients - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074111

Enrollment

Registered

2024-09-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes

Interventions

Intervention1: cryopreserved platelet concentrates: pooled platelet concentrates (200ML) will be treated with cryoprotective agent (Di-methyl sufoxide, 5-6 % v/v), after proper mixing, platelet concen

Eligibility

Inclusion criteria

Inclusion criteria: adult patients (18 years or more), both male and females, platelet transfusion are indicated, hemodynamically stable patients, platelet counts less than or equal to 50000/ul, bot PT and aPTT tests have values less than or equal to 1.5 times the normal value

Exclusion criteria

Exclusion criteria: presence of active/frank bleeding, head injury patients, patients with genetic bleeding disorders, patients unable to consent

Design outcomes

Primary

Measure	Time frame
Change in MAXIMUM CLOT FIRMNESS (MCF) on ROTEM parameters (viscoelastic testing) from pre-transfusion levelsTimepoint: at 1-2 hours after platelet transfusion	—

Secondary

Measure	Time frame
change in platelet counts before and after transfusion of platelet componentTimepoint: 1-2 hours and 18-24 hours	—

Countries

India

Contacts

Public ContactRAHUL CHAURASIA

AIIMS, NEW DELHI

drrahulchaurasia@gmail.com919560345917

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026