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Enhancing Patient Outcomes in Complex Surgeries: A Comparative Analysis of Goal-Directed Fluid Therapy versus Standard Protocols in Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy

Assessing the Impact of Goal-Directed Fluid Therapy Protocol on Perioperative Outcomes in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: A Comparison with Standard Institutional Fluid Therapy Protocol - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/074087
Enrollment
60
Registered
2024-09-20
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C169- Malignant neoplasm of stomach, unspecified

Interventions

Intervention1: Gold Directed Fluid Therapy: Gold Directed Fluid Therapy using flotrac/vigileo. THis monitoring will be done throughout the surgery and in the post-operative period in ICU. Control Inte

Sponsors

AIIMS, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Agree to participate in the study and sign written informed consent. 2. ASA-PS grade I /II or III patients posted for CRS and HIPEC surgery.

Exclusion criteria

Exclusion criteria: 1.Known case of liver dysfunction or renal dysfunction 2.Known coagulation disorder 3.COPD with FEV1 4.Left Ventricular Ejection Fraction 5.Allergic to any drug used during the study

Design outcomes

Primary

MeasureTime frame
Post-operative Renal complications in terms of AKIN classification and improvement in AKITimepoint: At baseline and immediately after surgery and 24 hrs post-surgery.

Secondary

MeasureTime frame
a) Intraoperative and post-operative serum lactate levels. b) Post-operative length of stay in the Intensive Care Unit (ICU) until the patient is deemed fit for discharge. c) 30-day mortality rate after the surgery.Timepoint: a) 24 hours c) 30 days

Countries

India

Contacts

Public ContactDr Raghav Gupta

All India Institute of Medical Sciences (AIIMS)

raghavgupta88@gmail.com8130622963

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026