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Microscopic and molecular examination of cells collected from mouth in suspected as well as obvious cancerous lesions of oral cavity.

Micronuclear Frequency in Buccal Smear and its Correlation with Histopathological Dysplasia, p53 and p16 Expression in Oral Potentially Malignant Disorders and Squamous Cell Carcinoma - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/09/074062
Enrollment
100
Registered
2024-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C060- Malignant neoplasm of cheek mucosa

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Nil Ratan Sircar Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients with suspected pre-malignant or oral squamous cell carcinoma lesions.

Exclusion criteria

Exclusion criteria: 1) Oral lesions with overt secondary infection. 2) Recurrent cases undergoing recent surgery or radiotherapy. 3) Patients who will deny consent. 4) Histologically diagnosed cases of non-squamous cell malignant or pre malignant lesions.

Design outcomes

Primary

MeasureTime frame
To evaluate the micronuclear frequency in buccal smear of oral potentially malignant disorders and suspected oral squamous cell carcinoma lesions and to detect its association with histopathological dysplasia, p53 and p16 expressionTimepoint: Month 14—

Secondary

MeasureTime frame
1. To estimate the proportion of patients showing dysplasia and micronuclear frequency in collected buccal smears. 2. To evaluate the histopathological diagnosis of the biopsy specimens. 3. To find out IHC interpretation of OSCC and dysplastic oral potentially malignant disorders using p53 and p16 markers. 4. To correlate micronuclear frequency with cytological as well as histological dysplasia and IHC findings. Timepoint: Month 14—

Countries

India

Contacts

Public ContactDr Asmita Chakrabarti

Nil Ratan Sircar Medical College and Hospital

asmitachakrabarti68@gmail.com8420022141

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026