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EFFICACY OF EARLY GLARGINE DIABETIC KETOACIDOSIS MANAGEMENT

EFFICACY OF EARLY GLARGINE PLUS STANDARD IV INSULIN VERSUS STANDARD IV INSULIN IN PATIENTS WITH DIABETIC KETOACIDOSIS: A RANDOMISED CONTROLLED TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/074053
Enrollment
76
Registered
2024-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E081- Diabetes mellitus due to underlying condition with ketoacidosis

Interventions

Intervention1: Intravenous Insulin plus subcutaneous Glargine: S/c Glargine will be given is dose of 0.3U/kg to patients with diabetic ketoacidosis within 4hours of diagnosis in addition to standard I

Sponsors

Department of Emergency Medicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Age = 18years diagnosed with DKA

Exclusion criteria

Exclusion criteria: 1. Patient in Shock requiring inotropes 2. Patients who received treatment for DKA prior to the arrival to emergency 3. Patient diagnosed with advanced liver disease 4. Patient diagnosed with advanced kidney disease 5. Pregnant patient 6. Patient who are known allergic to glargine

Design outcomes

Primary

MeasureTime frame
To compare the time duration in resolution of diabetes ketoacidosis between patient receiving early glargine with standard insulin versus patients receiving standard insulin therapy aloneTimepoint: To be assesed every 4hour along with blood gas reports till the resolution of diabetic ketoacidosis—

Secondary

MeasureTime frame
To compare occurrence of complications like hypoglycemia hypokalemia rebound hyperglycemia between patient receiving early glargine with standard insulin versus patients receiving standard insulin therapy alone.Timepoint: Till 24 hrs after resolution of Diabetic ketoacidosis;To compare the duration of hospital stay between patient receiving early glargine with standard insulin versus patients receiving standard insulin therapy alone.Timepoint: Till patient is deemed eligible for discharge in accordance with treating physician.;To compare total insulin requirement in term of dose between patient receiving early glargine with standard insulin versus patients receiving standard insulin therapy alone.Timepoint: Till the resolution of diabetic ketoacidosis—

Countries

India

Contacts

Public ContactDr Nayer Jamshed

AIIMS NEW DELHI

jamshednayer@gmail.com9990345682

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026