Health Condition 1: K768- Other specified diseases of liver
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Amrita School of Medicine
Eligibility
Inclusion criteria
Inclusion criteria: 1. Acute severe liver injury 2. Acute liver failure 3. Acute Hepatitis with atypical features like: (a) Renal involvement (Serum Creatinine greater than 1.3 mg/dl and/or early initiations of renal replacement therapy and/or hemolytic uremic syndrome) (b) Pulmonary involvement as evidenced by new onset infiltrates in chest radiography or increased FiO2 requirement or elective mechanical ventilation. (c) Evidence of Hemophagocytic Lymphohistiocytosis (HLH) as H score greater than or equal to 165 or raised serum ferritin levels greater than 1500 µg/L, triglycerides greater than 250 mg/dl, LDH greater than 300 U/L, and fibrinogen less than 250 mg/dl. (d) Neurological involvement characterized by focal neuro deficit or autoimmune neuropathy or Guillain Barre Syndrome. (e) Prominent GI symptoms
Exclusion criteria
Exclusion criteria: 1. Significant intake of hepatotoxic drugs 2. HIV 3. Malignancies 4. Acute HBV, HCV
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. To perform gene sequencing and HAV RNA PCR in select samples. 2. To determine predictors of mortality 3. To conduct epidemiological surveillance to map the source of the outbreak.Timepoint: 3 months | — |
Primary
| Measure | Time frame |
|---|---|
| To investigate the clinico-pathological profile and outcomes of the Hepatitis A related liver injury outbreak in KeralaTimepoint: 3 months | — |
Countries
India
Contacts
Public ContactArun K Valsan
Amrita Institute of Medical Science
Outcome results
None listed