Health Condition 1: F05- Delirium due to known physiological condition
Conditions
Interventions
Intervention1: Dexmedetomidine: compare the sedation with dexmedetomidine I.v (loading dose of 0.5 µg/kg and maintenance dose 0.2-0.4 µg/kg/h) on post op delirium.sedation will be started post induct
Sponsors
lady hardinge medical college
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing lower limb surgery under central neuraxial blockade; age more than 60 years; ASA physical status grade I- III
Exclusion criteria
Exclusion criteria: Patients with a history of psychosis or long-term psychotropic medication use/ benzodiazepine use/chronic analgesic drugs, or history of alcohol/nicotine abuse. Patients with evidence of severe infection (Total leucocyte count more than 14000 cells/cu.mm). Patients with communication barrier (severe audiovisual impairment or inability to speak or inability to understand Hindi or English language). Baseline Mini-Mental State Examination (MMSE) score of less than or equal to 23
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients developing postoperative delirium as assessed by DSM -5 criteria in both the groups i.e., group D and group KTimepoint: baseline and at postoperative day 2 | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in levels of IL-6 in pg/ml and CRP in mg/ml from preoperative period to postoperative day 2 (T2) in both the groups. Proportion of patients developing intraoperative side effects such as bradycardia, tachycardia, hypertension, hypotension and desaturation in both the groups. Correlation between occurrence of postoperative delirium and the expression of inflammatory markers.Timepoint: post op day 2 | — |
Countries
India
Contacts
Public ContactVignesh A S
Lady Hardinge Medical College
Outcome results
None listed