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Comparison between two drugs for decreasing pain after surgeries for bladder cancer

Effect of oral flavoxate on postoperative catheter related bladder dysfunction in adult males undergoing transurethral resection of bladder tumors- A randomized controlled trial vs solifenacin and placebo - Nil

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/073950
Enrollment
144
Registered
2024-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Oral flavoxate: Oral flavoxate 200 mg administered orally in the preoperative area 2 hour prior to surgery Control Intervention1: Oral solifenacin: Oral solifenacin 5 mg administered or

Sponsors

Dr. Nandyala Tejeswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult males ASA 2 & 3, posted for elective transurethral resection of bladder tumor surgeries for non-invasive bladder tumors

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Psychosis 3. Patients on preoperative anti-muscarinic drugs 4. Arrhythmias 5. Patients with pre-operative catheters

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative catheter related bladder dysfunctionTimepoint: At 6 hours postoperatively—

Secondary

MeasureTime frame
Incidence of postoperative catheter related bladder dysfunctionTimepoint: At 0 hours[PACU] 1 hour, 2 hours, 12 hours & 24 hours postoperatively;Incidence of severe CRBDTimepoint: At 0[PACU], 1, 2, 6 , 12 & 24 hours postoperatively;Incidence of side effects of the flavoxate & solifenacin like dry mouth, constipation, headache, & dizzinessTimepoint: At 24 hours postoperatively;Visual analog scoreTimepoint: At 0 hour [PACU], 1 hour, 2 hours, 6 hours, 12 hours & 24 hours postoperatively;Patient satisfaction with the interventions for decreasing catheter related bladder discomfortTimepoint: At 6 hours—

Countries

India

Contacts

Public ContactDr Satyajeet Misra

AIIMS Bhubaneswar

misrasatyajeet@gmail.com9438884048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 9, 2026