Health Condition 1: L700- Acne vulgaris
Conditions
Interventions
Intervention1: METFORMIN,
DOXYCYCLIN
: METFORMIN oral tablet metformin 500 mg twice daily for 3 months.
DOXYCYCLIN oral tablet 100 mg twice daily for 3 months
Intervention2: DOXYCYCLIN: Oral Tablet
Sponsors
Uttar Pradesh University of Medical Sciences Saifai
Eligibility
Inclusion criteria
Inclusion criteria: 1. Moderate-to-severe acne 2. Who had not received systemic or topical treatment in the past 4 weeks ( systemic antibiotics, retinoids, corticosteroids or immunosuppressive agents)
Exclusion criteria
Exclusion criteria: 1. Patients with systemic diseases, including diabetes mellitus, kidney/liver dysfunction, 2. Pregnant and lactating women, 3. Those who are reluctant to come for regular follow up, 4. Those who reported a positive history of allergy to the study drugs, 5. Those who used drugs that interact with metformin or doxycycline, 6. Those who used contraceptive medications containing estrogen or progesterone, 7. Addiction to smoking and alcohol, 8. History of migraine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage change in inflammatory and total lesion counts at baseline , 4 weeks, 8 weeks, and 12 weeks.Timepoint: at baseline, 4 weeks, 8 weeks, and 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| improvement in GAGS grading, improvement in CADI score at week 12Timepoint: at baseline, 12 weeks. | — |
Countries
India
Contacts
Public ContactKAPIL KAKTAN
UTTAR PRADESH UNIVERSITY OF MEDICAL SCIENCES
Outcome results
None listed