How light activated treatment and chemotherapy together can improve outcomes in locally advanced oral cancers

Impact of addition of 5- aminolevulinic acid induced photodynamic therapy to neoadjuvant chemotherapy in locally advanced oral squamous cell carcinoma - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073916

Enrollment

Registered

2024-09-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx

Interventions

Intervention1: 5-Aminolevulinic acid Photodynamic therapy: One group of patients will recieve 5- Aminolevulinic acid Photodynamic therapy with Neoadjuvant chemotherapy once in 21 days. 10% Amino levul

Eligibility

Inclusion criteria

Inclusion criteria: Patients with biopsy proven oral squamous cell carcinoma age group between 40-65 years with Stage T4a and T4b

Exclusion criteria

Exclusion criteria: 1.Patients with history of earlier radiotherapy 2.Second primary cancers 3.Patients with tumour bleed, tumour encasing major blood vessels 4.Hypersensitivity to 5-aminolevulinic acid 5.Oral malignancies that have recurred after treatment.

Design outcomes

Primary

Measure	Time frame
Tumour size and VolumeTimepoint: 0, 57th Day	—

Secondary

Measure	Time frame
Tumour resectabilityTimepoint: 0, 57th Day	—

Countries

India

Contacts

Public ContactDr S M AZEEM

sri devaraj urs university of higher education and research

azeem_hn@yahoo.co.in9845373279

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026