Health Condition 1: E518- Other manifestations of thiamine deficiency
Conditions
Interventions
Intervention1: Addition of Thiamine to Standard Care for management of Pulmonary Arterial Hypertension: Addition of Thiamine to Standard care (Oxygen/Sildenafil)
Thiamine is given at a dose of 100mg/
Sponsors
Individual Principal Investigator Name Mampy Das
Eligibility
Inclusion criteria
Inclusion criteria: Infants aged 1month to 12months presenting with respiratory distress, as evidenced by signs such as tachypnea, retractions, grunting, or cyanosis.
Exclusion criteria
Exclusion criteria: The project has two sets of exclusion criteria: 1. Exclusions before enrollment to the prevalence study: i.Infants diagnosed with structural heart defects except a small (less than 5mm) atrial septal defect or a small (less than 2mm) patent foramen ovale. ii. Infants diagnosed with chronic lung disease. 2. Exclusions to the intervention study: i.Infants who have recently received supplementation with thiamine containing Multivitamins. ii. Patient on predominantly formula feeds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of Pulmonary Arterial HypertensionTimepoint: At 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Impact of thiamine supplementation on clinical outcomes, including oxygenation and heart rateTimepoint: At 72 hours | — |
Countries
India
Contacts
Public ContactMampy Das
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences
Outcome results
None listed