Efficacy of plasma exchange along with Standard Medical Treatment in comparison to Standard Medical Treatment alone in patients with acute on chronic failure

Efficacy of plasma exchange in patients with acute on chronic Liver failure A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073862

Enrollment

Registered

2024-09-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system

Interventions

Intervention1: PLEX arm: Plasmapheresis along with Standard Medical Treatment. 3 sessions of plasmapheresis will be targeted on alternate days during the hospital stay of the patient and Standard Medi

Eligibility

Inclusion criteria

Inclusion criteria: All ethologies of ACLF as per APASAL criteria will be included in the study.

Exclusion criteria

Exclusion criteria: Active sepsis Hemodynamic instability HIV infection Malignancy HCC Pregnancy Alcoholic hepatitis and Severe Alcoholic hepatitis

Design outcomes

Primary

Measure	Time frame
To compare survival over 30 days in PLEX and SMT armTimepoint: To compare survival over 30 days in PLEX and SMT arm	—

Secondary

Measure	Time frame
Improvement in renal dysfunction Improvement in hepatic encephalopathy Duration of hospital stay PLEX related complications Serial plasma levels of vWFTimepoint: 30 days	—

Countries

India

Contacts

Public ContactDr Manasvin Sareen

SMS Medical College and Hospital , Jaipur

sandeepnijhawan16@gmail.com9829272233

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026