A RCT to evaluate the role of absorbable antimicrobial sutures in comparison to conventional sutures in the prevention of SSI

A Randomized control trial to evaluate the role of absorbable antimicrobial sutures in comparison to conventional sutures in the prevention of surgical site infections - nil

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073751

Enrollment

Registered

2024-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L763- Postprocedural hematoma and seromaof skin and subcutaneous tissue following a procedure

Interventions

Intervention1: absorbable antimicrobial sutures: Triclosan as a broad spectrum antiseptic is known from in vitro and in vivo studies to reduce the adherence of selective clinical Gram- positive, Gram-

Eligibility

Inclusion criteria

Inclusion criteria: • Adult patients (=18 years) undergoing surgery at the participating hospital • Elective abdominal surgeries (Open abdominal surgery is defined as surgically opened peritoneal cavity. • Ability to provide informed consent

Exclusion criteria

Exclusion criteria: 1. Bowel/Gastric Perforation 2. Any drug, alcohol, or nicotine abuse – People with mental disorders 3. Participants under 18 years 4.Emergency surgery/procedures 5.Not willing to participate in the study) • Pregnant or breastfeeding women • Immunocompromised patients • Patients with known hypersensitivity to any of the components of the suture material • Patients with a pre-existing infection at the surgical site

Design outcomes

Primary

Measure	Time frame
Incidence of Surgical Site Infection within 30 days post surgeryTimepoint: Incidence of Surgical Site Infection within 30 days post surgery at 7thDay, 15th day and 30th day	—

Secondary

Measure	Time frame
• Evaluate the safety profile: The trial also aims to assess the safety profile of absorbable antimicrobial sutures compared to standard absorbable sutures. This includes monitoring for any adverse events or complications associated with the use of antimicrobial sutures, such as allergic reactions or tissue irritation. • Assess wound healing: The study may include an evaluation of wound healing outcomes between the two suture groups. This could involve monitoring wound closure, presence of wound complications (e.g., dehiscence), and overall wound healing progression. • Compare surgical outcomes: The trial will investigate other surgical outcomes related to the use of absorbable antimicrobial sutures, such as surgical site complications (e.g., seroma formation, hematoma), length of hospital stay, or the need for additional surgical interventions. Timepoint: 30 days	—

Measure

Time frame

• Evaluate the safety profile: The trial also aims to assess the safety profile of absorbable antimicrobial sutures compared to standard absorbable sutures. This includes monitoring for any adverse events or complications associated with the use of antimicrobial sutures, such as allergic reactions or tissue irritation. • Assess wound healing: The study may include an evaluation of wound healing outcomes between the two suture groups. This could involve monitoring wound closure, presence of wound complications (e.g., dehiscence), and overall wound healing progression. • Compare surgical outcomes: The trial will investigate other surgical outcomes related to the use of absorbable antimicrobial sutures, such as surgical site complications (e.g., seroma formation, hematoma), length of hospital stay, or the need for additional surgical interventions. Timepoint: 30 days

—

Countries

India

Contacts

Public ContactSoumya Tripathi

UPUMS Saifai

somendrachauhan@hotmail.com9719101511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026