Comparison of efficacy of high flow nasal cannula versus non rebreathing mask during endotracheal intubation

Efficacy of High Flow Nasal Cannula Versus Non- Rebreathing Mask During Endotracheal Intubation In critically ill Children : A Randomised Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073734

Enrollment

180

Registered

2024-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J960- Acute respiratory failure Health Condition 2: J969- Respiratory failure, unspecified Health Condition 3: J969- Respiratory failure, unspecified

Interventions

Intervention1: HEATED HUMIDIFIED HIGH FLOW NASAL CANNULA: The preoxygenation will be performed by either HFNC with 100% FiO2 with 2l/kg/min for 4 minutes.The frequency will be decided by randomisation

Eligibility

Inclusion criteria

Inclusion criteria: All male and female patients from 1 month to 18 years requiring elective endotracheal intubation.

Exclusion criteria

Exclusion criteria: Endotracheal intubation for cardiac arrest. Emergent endotracheal intubation is indicated for conditions such as bradycardia, ventricular fibrillation, and heart block. Nasopharyngeal obstruction with midline facial deformities of the jaw, nose, and larynx. Children with chromosomal anomalies. Children requiring reintubation. Children unable to achieve saturation greater than 90% after preoxygenation for 4 minutes.

Design outcomes

Primary

Measure	Time frame
Lowest saturationTimepoint: Lowest oxygen saturation from the start of laryngoscopy insertion until connection to the ventilator.	—

Secondary

Measure	Time frame
Difficult intubationTimepoint: Two failed attempts at direct laryngoscopy & one attempt will be counted as 30 seconds.;Time required for intubationTimepoint: From the insertion of the laryngoscope to the connection to the ventilator.;Organ failureTimepoint: During the first five days in the PICU, the assessment will be conducted using the PELOD score.;Complications During Endotracheal IntubationTimepoint: During endotracheal intubation & the subsequent hour.;Time on ventilatorTimepoint: The duration will be calculated in days, starting from the day of intubation on the mechanical ventilator to the day of extubation.;Length of hospital stayTimepoint: From the commencement of successful intubation to the point of hospital discharge.;Ventilator associated pneumoniaTimepoint: Achieving a score greater than 6 on the CPIS scale will result in the absolute number of patients being considered.	—

Measure

Time frame

Difficult intubationTimepoint: Two failed attempts at direct laryngoscopy & one attempt will be counted as 30 seconds.;Time required for intubationTimepoint: From the insertion of the laryngoscope to the connection to the ventilator.;Organ failureTimepoint: During the first five days in the PICU, the assessment will be conducted using the PELOD score.;Complications During Endotracheal IntubationTimepoint: During endotracheal intubation & the subsequent hour.;Time on ventilatorTimepoint: The duration will be calculated in days, starting from the day of intubation on the mechanical ventilator to the day of extubation.;Length of hospital stayTimepoint: From the commencement of successful intubation to the point of hospital discharge.;Ventilator associated pneumoniaTimepoint: Achieving a score greater than 6 on the CPIS scale will result in the absolute number of patients being considered.

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Countries

India

Contacts

Public ContactDr ANIL SACHDEV

Sir Gangaram hospital ,rajinder nagar , new delhi 110060

thaparoshni219@gmail.com07051903519

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026