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Compare effect of Granisetron vs Lignocain in allevating the pain induced by propofol in patients undergoing general anaesthesia

A comparative study of clinical efficacy of pretreatment between intravenous Granisetron and intravenous Lignocaine to allaevate pain on Propofol injection during general anaesthesia. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/073695
Enrollment
100
Registered
2024-09-10
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: G group - Granisetron 2mg/2ml IV: Granisetron 2mg/2ml IV injection given prior to injection propofol induction agent Control Intervention1: L group - Lignocaine 40mg/2ml IV: Injection l

Sponsors

Dr Nitin S Kunnoor
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants scheduled for elective surgeries under General Anaesthesia (GA) 2. Participants with American Society of Anaesthesiologists (ASA) physical status Grade I & II 3. Age 18-60 years, weighing between 40 – 80 kgs of all genders

Exclusion criteria

Exclusion criteria: 1. Emergency surgeries under GA 2. Participantswith history of allergy to specified drugs and its congeners in study. 3. Participants received any sedatives, analgesics within last 12 hours before procedure 4. Pregnant and lactating women 5. Participants with communication problems & Psychiatric Disorder

Design outcomes

Primary

MeasureTime frame
intravenous granisetron, being a potent 5HT3antagonist might decrease pain (by 50%) caused by iv injection of propofolTimepoint: 8 hours—

Secondary

MeasureTime frame
Reduction in post operative nausea and vomiting up to 8 hours Haemodynamic changes ; ADRTimepoint: 8 hours—

Countries

India

Contacts

Public ContactDr Nitin S Kunnoor

Mahadevappa Rampure Medical College and Hospital

pratimab1975@gmail.com9972166344

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026