Comparison of two intravenous drugs(Dexmedetomidine with Ketamine and Dexmedetomidine with Fentanyl) for passing tube (Endotracheal tube) via nose with help of Instrument (fiber scope) in patients without anaesthesia (in awake patients)

Comparison between IV Dexmedetomidine with Ketamine and IV Dexmedetomidine with Fentanyl on Intubating Conditions During Awake Fibreoptic Intubation: A Prospective Randomised Double Blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073684

Enrollment

Registered

2024-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H720- Central perforation of tympanic membrane Health Condition 2: G542- Cervical root disorders, not elsewhere classified Health Condition 3: H711- Cholesteatoma of tympanum Health Condition 4: H701- Chronic mastoiditis Health Condition 5: G892- Chronic pain, not elsewhere classified Health Condition 6: M265- Dentofacial functional abnormalities Health Condition 7: S120- Fracture of first cervical vertebra Health Condition 8: S320- Fracture of lumbar vertebra Health Conditio

Interventions

Intervention1: AWAKE FIBEROPTIC INTUBATION: Comparison between IV Dexmedetomidine (1mcg/kg) with Ketamine(40mg) and IV Dexmedetomidine(1mcg/kg) with Fentanyl(2mcg/kg) on intubating condition during aw

Eligibility

Inclusion criteria

Inclusion criteria: Patient with ASA Grade I and II Patient undergoing elective surgery under general anaesthesia Patient with Mallampati Class I and II

Exclusion criteria

Exclusion criteria: Patient refusal Psychiatric patients Emergency surgery Patients with severe bradycardia/heart block Pregnant and lactating mother Patients having known allergy to any drug used in the study Patients contraindicated to nasal intubation such as grossly distorted airway anatomy, URTI and bleeding disorders Patients on long term opioids or sedative medications

Design outcomes

Primary

Measure	Time frame
Cough score(severity of cough) during awake fibreoptic intubationTimepoint: Up to 2 Min after awake fibreoptic intubation	—

Secondary

Measure	Time frame
Intubating conditions Vocal cord position Post intubation score Ramsay sedation score Hemodynamic parameters Side effects/complications if anyTimepoint: Up to 24-hours postoperatively	—

Countries

India

Contacts

Public ContactDr Shrikrishan Choudhary

R.N.T Medical College

sharma0979@yahoo.co.in09214323557

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026