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Effects of dexamethasone and pheniramine maleate on blood pressure,heart rate,mean blood pressure and oxygen saturation in total hip replacement after cementation

Effects of dexamethasone and pheniramine maleate on hemodynamic and respiratory parameters after cementation in total hip replacement - nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/073639
Enrollment
40
Registered
2024-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: S720- Fracture of head and neck of femur

Interventions

Intervention1: Dexamethasone 8 mg and Pheniramine maleate 45.5 mg,total 4 ml: Dexamethasone 8 mg and Pheniramine maleate 45.5 mg,total 4 ml Intravenous route of administration Given 30 min before op

Sponsors

Health and family welfare departmentGoverment of Gujarat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status II, III Patients undergoing total hip replacement surgeries Duration of surgery: around two to three hours. Willing to give informed consent

Exclusion criteria

Exclusion criteria: ASA status IV, V Emergency surgeries Patients refusing to give consent Patient with a fever of any cause Known allergy to bone cement Patients with allergic diseases, using antiallergic medications or corticosteroids Patients having deep venous thrombosis and lower extremity venous insufficiency Patients with cardiac disease likely to cause atrial fibrillation or thromboembolism or paraplegia, hemiplegia, bedridden patients Patient with a history of past cardiac surgery Patient having contraindications for regional anesthesia

Design outcomes

Primary

MeasureTime frame
Intra operative Respiratory and Hemodynamic vitals stabilityTimepoint: Intra operative period

Secondary

MeasureTime frame
Incidence of Bone cement implantation syndrome & Use of Adrenaline & Atropine after cementation with Prophylactic use of Dexamethasone & Pheniramine maleateTimepoint: Intra operative period

Countries

India

Contacts

Public ContactAtul B vyas

B.J.Medical College

atulvyas12027@yahoo.com9898212482

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026