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Comparing the Effects of Remote Ischemic Post-Conditioning and a Sham Treatment on Jugular Venous Oxygen Levels and Three-Month Neurological Outcomes in Patients Undergoing Surgery for Intracranial Aneurysms - A Randomized Controlled Trial

Effect of Remote Ischemic Post-Conditioning Vs Sham on Jugular Venous Oximetry and three-month neurological outcomes in patients Undergoing Intracranial Aneurysmal Clipping: A Randomized controlled trial. - nil

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/073599
Enrollment
50
Registered
2024-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery

Interventions

Intervention1: Group R/ True RIPC: In patients randomised to Group R, blood pressure cuff will be placed in the upper extremity and kept inflated to 30 mmHg above the baseline systolic blood pressure

Sponsors

All India Institute of Medical Sciences, Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Consent by the patient or closest of kin ASA grade I-IV individuals Aged 18-65years, scheduled for surgical clipping of the ruptured aneurysm during the study period Patients presenting up to 7 days of ictus. Modified Hunt and Hess Grade 1 to 3

Exclusion criteria

Exclusion criteria: Patients not willing to give consent Hunt and Hess Grade more than 3 Patients requiring inotropic support preoperatively DVT and history of peripheral vascular disease

Design outcomes

Primary

MeasureTime frame
To assess the effect of RIPC on Cerebral Oxygenation as measured on jugular venous catheter (SjvO2) at 24hours after aneurysm clippingTimepoint: 24hours after aneurysm clipping—

Secondary

MeasureTime frame
Incidence of cerebral deoxygenation in the two group within 7 days after surgery.Timepoint: 7 days;Days spent in Vasospasm diagnosed by TCD between groupsTimepoint: 7 days post op or until discharge from ICU;Quantitative Troponin I level at 48hrs in between groups.Timepoint: 48hrs after aneurysm clipping;CT-Angiography and Perfusion CT on POD 7 to assess mean transit time (MTT), cerebral blood flow (CBF) and cerebral blood volume (CBV).Timepoint: post op day 7;GOSE and Modified Rankin ScalesTimepoint: at discharge and 3months—

Countries

India

Contacts

Public ContactDr Divya M
divya.924a@gmail.com8861934256

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026