Comparison of different doses of morphine given in spinal space on pain relief after surgery in in renal transplant patients

Comparison Of Two Different Doses Of Intrathecal Morphine On Postoperative Analgesia In Renal Transplant Recipients. A Non-Inferiority Randomised Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073572

Enrollment

Registered

2024-09-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N186- End stage renal disease

Interventions

Intervention1: Intrathecal 200 Group received 200 micrograms of intrathecal morphine: Route of administration: intrathecal space Dose: 0.2 mg of preservative-free morphine. Frequency: single dose at i

Eligibility

Inclusion criteria

Inclusion criteria: All living donor kidney transplant patients with age more than 18 years will be included in the study.

Exclusion criteria

Exclusion criteria: Refusal to give informed consent, Contraindications to regional block, Patients undergoing additional transplant, Deceased donor kidney transplant patients,Recent use of analgesic medication

Design outcomes

Primary

Measure	Time frame
The primary outcome will be to assess pain score using Visual Analogue scale (VAS) at rest postoperativelyTimepoint: VAS at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours	—

Secondary

Measure	Time frame
Cumulative opioid consumptionTimepoint: 24h, 48h and 72 hours;Incidence respiratory depressionTimepoint: RR at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Length of stay in the hospitalTimepoint: At discharge;Need for rescue analgesia for severe painTimepoint: Need for rescue analgesia at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Occurrence of pruritis and postoperative nausea and vomiting ( PONV)Timepoint: ONV/Prurits at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Quality of recovery score (QoRS) 15 scoreTimepoint: 24h, 48h and 72 hours;RASS sedation scoreTimepoint: RASS at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Time to return of bowel movementsTimepoint: Time in days to return of bowel movements	—

Measure

Time frame

Cumulative opioid consumptionTimepoint: 24h, 48h and 72 hours;Incidence respiratory depressionTimepoint: RR at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Length of stay in the hospitalTimepoint: At discharge;Need for rescue analgesia for severe painTimepoint: Need for rescue analgesia at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Occurrence of pruritis and postoperative nausea and vomiting ( PONV)Timepoint: ONV/Prurits at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Quality of recovery score (QoRS) 15 scoreTimepoint: 24h, 48h and 72 hours;RASS sedation scoreTimepoint: RASS at (Arrival in recovery), 2h, 6h, 24 h, 48 hr, 72 hours;Time to return of bowel movementsTimepoint: Time in days to return of bowel movements

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Countries

India

Contacts

Public ContactKamal Kajal

Postgraduate Institute of Medical Education and research, Chandigarh

kamal.kajal@gmail.com09560412726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026