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COMPARISON OF REVERSAL OF MUSCLE RELAXATION PRODUCED BY VECURONIUM WITH EITHER SUGAMMADEX OR NEOSTIGMINE+GLYCOPYRROLATE IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES UNDER BALANCED GENERAL ANAESTHESIA

COMPARISON OF REVERSAL OF VECURONIUM INDUCED MODERATE TO DEEP NEUROMUSCULAR JUNCTION BLOCKADE BY SUGAMMADEX VS COMBINATION OF NEOSTIGMINE+GLYCOPYRROLATE IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES UNDER BALANCED GENERAL ANAESTHESIA- A RANDOMISED CONTROLLED TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/09/073566
Enrollment
60
Registered
2024-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Neostigmine+ glycopyrrolate: It a gold standard reversal agent used to reverse the effects of non-depolarizing agents, to antagonise the residual effects as well as to accelerate the re

Sponsors

Adesh institute of medical sciences and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Elective surgery under Balanced General anaesthesia 2 ASA grade- I/ II

Exclusion criteria

Exclusion criteria: 1 Emergency surgeries 2 Patients having neuromuscular disorders 3 Surgeries not requiring endotracheal intubation 4 Patient on drugs known to interfere with neuromuscular transmission 5 Patients with hepatic or renal diseases 6 Allergic to Vecuronium , opioids, other medication used during general anaesthesia

Design outcomes

Primary

MeasureTime frame
To Find out the mean recovery time and adequate depth of anaesthesia for the reversal of the moderate to deep neuromuscular junction blockade produced by Vecuronium By Sugammadex Vs Neostigmine and glycopyrrolateTimepoint: Before the Induction, At the time of induction & administration of Vecuronium, Intraoperatively, Time at which reversal is given, Time of extubation, Time at which patient is shifted to post- op recovery room(RR), time at which the patient demands rescue analgesia or 2 hours post-operatively, whichever comes first—

Secondary

MeasureTime frame
Find out the Side effects and Haemodynamic changes of administration of Injection Sugammadex with Vecuronium induced neuromuscular blockadeTimepoint: 1. T0: Before the Induction 2. T1: At the time of induction & administration of Vecuronium 3. T2: Intraoperatively 4. T3: Time at which reversal is given 5. T4: Time of extubation 6. T5: Time at which patient is shifted to post- op recovery room(RR) 7. T6: time at which the patient demands rescue analgesia or 2 hours post-operatively, whichever comes first. Inj Ketorolac 30mg diluted in 100 ml Normal Saline over period of 10-15 minutes intravenously shall be used as rescue analgesia.—

Countries

India

Contacts

Public ContactDr MRIDUL M PANDITRAO

AIMSR

drmmprao1@gmai.com8699921884

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026