To study the effect of preoperative Dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation in patients undergoing elective surgeries under general anaesthesia

Effect of preoperative Dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation in general anaesthesia - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073498

Enrollment

Registered

2024-09-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Does nebulization with dexmedetomidine blunt the hemodynamic response during laryngoscopy and endotracheal intubation when compared with NS: 1 year and 3 months Control Intervention1:

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients of either sex, aged between 18-60 years age and willing to participate. 2. American Society of Anaesthesiologists (ASA) I and II status 3. Patients undergoing elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: 1. Anticipated difficult airway. 2. History of hypertension , on antihypertensives 3. Cardiovascular diseases 4. Treatment with beta blockers and calcium channel blockers, or any other drug causing hemodynamic instability 5. Laryngoscopy time more than 30 seconds 6. Allergic to dexmedetomidine 7. Pregnant and lactating mothers 8. Patients refusal to participate in study 9. Patients posted for emergency surgeries

Design outcomes

Primary

Measure	Time frame
Heart rate through continous ECG monitor at before nebulisation, after nebulisation ,during laryngoscopy and intubation and 1,3,5 and 10 minutes after that intubation.Timepoint: after nebulisation during laryngoscopy and intubation 1 min 3 min 5 min 10 minutes	—

Secondary

Measure	Time frame
Systolic blood pressure, Diastolic blood pressure & Mean Arterial Pressure) will be measured by noninvasive blood pressure(NIBP) monitoring before nebulisation, after nebulisation ,during laryngoscopy & intubation & 1,3,5 & 10 minutes after intubation.Timepoint: after nebulisation during laryngoscopy & intubation 1 min 3 min 5 min 10 minutes	—

Countries

India

Contacts

Public ContactHIMANI SHARMA

Maharaja Agrasen Medical College and Hospital

sheetalbhatia1234@gmail.com8950426301

Outcome results