Health Condition 1: P229- Respiratory distress of newborn, unspecified
Conditions
Interventions
Intervention1: High-frequency oscillatory ventilation with volume guarantee: Once recruited, neonates will be started on high-frequency oscillatory ventilation along with volume guarantee. The initial
Sponsors
All India Institute of Medical Sciences Rishikesh
Sriparna Basu
Eligibility
Inclusion criteria
Inclusion criteria: Neonates who fail conventional mechanical ventilation and require high-frequency oscillatory ventilation as a rescue mode. CMV failure will be defined as the presence of any of the following 1. Peak positive pressure more than 26 cm H2O 2. Mean airway pressure more than 12 cm H2O 3. Diffuse atelectasis in chest x-ray requiring lung recruitment 4. Refractory respiratory acidosis defined as pCO2 more than 60 mmHg and or pH less than 7.20 5. Air leak syndrome in conventional mechanical ventilation
Exclusion criteria
Exclusion criteria: Major congenital malformations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypo or hypercarbia at 1 hour after starting high frequency oscillatory ventilationTimepoint: At 1 hour | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of hypo or hypercarbia at 6, and 24 hours after starting HFOV 2. Any incidence of hypo or hypercarbia during HFOV 3. Total number of episodes of hypo or hypercarbia during HFOV 4. Measured high frequency tidal volume at 1, 6, 12, 24 and 48 hours as applicable 5. Cranial USG and cerebral blood flow in the anterior cerebral artery at baseline and one hour of HFOV 6. Regional cerebral oxygenation at baseline and one hour of HFOV 7. Duration of invasive mechanical ventilation 8. Duration of respiratory support in any form 9. Incidences of morbidities during hospital stay 10. Mortality 11. Duration of hospital stay Timepoint: During hospital stay | — |
Countries
India
Contacts
Public ContactSriparna Basu
All India Institute of Medical Sciences, Rishikesh
Outcome results
None listed