To compare the clinical outcomes of minimally invasive surgical procedures; minimally invasive surgical technique (MIST) and modified minimally invasive technique (M-MIST).

COMPARISION OF CLINICAL EFFICACY OF MINIMALLY INVASIVE SURGICAL TECHNIQUE (MIST) VERSUS MODIFIED- MINIMALLY INVASIVE SURGICAL TECHNIQUE (M-MIST) IN THE TREATMENT OF PERIODONTAL INFRABONY DEFECTS: A RANDOMIZED CONTROLLED CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073429

Enrollment

Registered

2024-09-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K05- Gingivitis and periodontal diseases

Interventions

Intervention1: Modified Minimally invasive surgical technique(M-MIST) with i-PRF.: M-MIST is based on the elevation of only buccal flap, which enhances the concept of MIST by avoiding the interdental

with the use of injectable platelet-rich fibrin (i-PRF). Control Intervention1: Minimally invasive surgical technique (MIST) with i-PRF.: MIST is based on the elevation of the defect associated interd

with use of injectable platelet-rich fibrin (i-PRF).

Eligibility

Inclusion criteria

Inclusion criteria: periodontitis (stage III-IV) Systematically healthy patient Contained infrabony defects

Exclusion criteria

Exclusion criteria: Patients who had received periodontal treatment within the previous three months. Pregnant or lactating Third molars Teeth with grade III mobility

Design outcomes

Primary

Measure	Time frame
To evaluate the clinical outcomes in terms of pocket probing depth (PPD) reduction, clinical attachment level (CAL) gain and bone fill (BF) in the treatment of periodontal infrabony defects.Timepoint: Final clinical and radiographic outcomes will be evaluated at 6 months follow-up.	—

Secondary

Measure	Time frame
1. To evaluate the early healing index of periodontal soft tissue wounds after the surgery. 2. To quantify radiographically, regeneration of interdental bone using CBCT. 3. To compare the clinical, radiological and patient centered outcomes of minimally invasive surgical technique (MIST) with the modified minimally invasive surgical technique (M-MIST).Timepoint: Subjects will be recalled after 7 days for evaluation of early wound healing index; at 3 months for soft tissue evaluation, and then the final clinical and radiographic outcomes will be evaluated at 6 months follow-up.	—

Measure

Time frame

1. To evaluate the early healing index of periodontal soft tissue wounds after the surgery. 2. To quantify radiographically, regeneration of interdental bone using CBCT. 3. To compare the clinical, radiological and patient centered outcomes of minimally invasive surgical technique (MIST) with the modified minimally invasive surgical technique (M-MIST).Timepoint: Subjects will be recalled after 7 days for evaluation of early wound healing index; at 3 months for soft tissue evaluation, and then the final clinical and radiographic outcomes will be evaluated at 6 months follow-up.

—

Countries

India

Contacts

Public ContactSaif Khan

Department of Periodontia and community dentistry

ndguptaligarh@gmail.com9412817009

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026