Comparison of Two Drugs for Reducing Heart Rate and Blood Pressure During Intubation in General Anesthesia

A comparative study between nebulized magnesium sulphate and dexmedetomidine for attenuation of hemodynamic response to larngoscopy and endotracheal intubation a double blinded randomized control study - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073422

Enrollment

Registered

2024-09-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: comparative study between nebulized magnesium sulphate and dexmedetomidine for attenuation of hemodynamic response to laryngoscopy and intubation: Group A:nebulized Dexmedetomidine 1mcg

Eligibility

Inclusion criteria

Inclusion criteria: Between 18 and 60 years ASA grade 1 and 2 Modified mallampatti grading 1 and 2

Exclusion criteria

Exclusion criteria: known case of drug allergies uncontrolled hypertension pregnant patients

Design outcomes

Primary

Measure	Time frame
To compare the alteration in heart rate from baseline pre nebulization to 1 minute after intubation in response to laryngoscopy and endotracheal intubationTimepoint: 0 min, 1 min	—

Secondary

Measure	Time frame
To observe the alteration in heart rate at other time points and observe alteration in systolic blood pressure, diastolic blood pressure, mean arterial pressure atTimepoint: HR-2 min after intubation,5min after intubation, 10 min after intubation BP- 0 min pre nebulization 1,2,5,10 minute post intubation	—

Countries

India

Contacts

Public ContactP Abenaya

Sri Venkateshwaraa medical college hospital and research center

dr.jayashridevi@gmail.com8754689690

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026