Study to compare the efficacy of intravenous phenylephrine infusion versus intravenous Ramosetron in the prevention of hypotension post spinal anaesthesia for patients undergoing elective surgery for inguinal hernia i.e. herniorhhaphy/hernioplasty

Study on comparison of prophylactic phenylephrine infusion versus intravenous ramosetron on hypotension during spinal anaesthesia for herniorhhaphy , hernioplasty : A Randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073332

Enrollment

Registered

2024-09-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K40-K46- Hernia Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Phenylephrine: In patients receiving prophylactic phenylephrine infusion i.v. infusion of phenylephrine(25 µg.min-1 ) will be started post puncture and continued for 30 minutes post spi

Eligibility

Inclusion criteria

Inclusion criteria: Adult patient ASA status type I or II. Patient of inguinal hernia undergoing Elective Surgery requiring spinal anaesthesia. Patient height between 160 c.m. – 170 c.m.

Exclusion criteria

Exclusion criteria: Patient having known allergy to any of medication to be used in the study(phenylephrine and ramosetron). Emergency cases. Patient having other comorbidities. ASA status type 3 and 4.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of intravenous phenylephrine infusion(25 µg.min-1) versus intravenous Ramosetron(0.3mg) versus 0.9% Normal saline (placebo) infusion in the prevention of hypotension post spinal anaesthesia for patients undergoing elective surgery for inguinal hernia i.e. herniorhhaphy/hernioplasty. Mean Arterial pressure , systolic and diastolic blood pressure and Heart rate will bw measured.Timepoint: pre induction post spinal puncture At every 2 minutes interval for first 15 minutes Then at every 5 minutes for next 15 minutes Then at every 10 minutes interval for rest of duration of surgery.	—

Measure

Time frame

To compare the efficacy of intravenous phenylephrine infusion(25 µg.min-1) versus intravenous Ramosetron(0.3mg) versus 0.9% Normal saline (placebo) infusion in the prevention of hypotension post spinal anaesthesia for patients undergoing elective surgery for inguinal hernia i.e. herniorhhaphy/hernioplasty. Mean Arterial pressure , systolic and diastolic blood pressure and Heart rate will bw measured.Timepoint: pre induction post spinal puncture At every 2 minutes interval for first 15 minutes Then at every 5 minutes for next 15 minutes Then at every 10 minutes interval for rest of duration of surgery.

—

Secondary

Measure	Time frame
To compare the incidence of episodes of nausea and vomiting between three groups. Timepoint: post spinal puncture till end of surgery.;To compare the incidence of episodes of skin flushing and other patient discomfort between three groups. Timepoint: post spinal puncture till end of surgery	—

Countries

India

Contacts

Public ContactDR BHARATI

RAJENDRA INSTITUTE OF MEDICAL SCIENCES

dipalishio@gmail.com9620310511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026