To compare efficacy of intravenous dexmedetomidine and ketamine combination versus dexmedetomidine alone on awake nasotracheal intubation in patients under general anesthesia

A randomized study to compare efficacy of intravenous dexmedetomidine and ketamine combination versus dexmedetomidine alone on awake nasotrachel intubation in patients under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073307

Enrollment

102

Registered

2024-09-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: G968- Other specified disorders of central nervous system

Interventions

Intervention1: Dexmedetomidine and ketamine combination: Patients will receive intravenous dexmedetomidine 1µg/kg over 10 minutes in 100 mL normal saline followed by intravenous ketamine 15mg as a bo

Eligibility

Inclusion criteria

Inclusion criteria: Patient consenting to participate belonging to American society of anaesthesiologists grade I & II with anticipated difficult intubation (modified mallampatti grade IV , limited cervical spine extension) undergoing elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Patient not consenting to participate and allergic to Dexmedetomidine / ketamine

Design outcomes

Primary

Measure	Time frame
To assess and compare intubating conditionsTimepoint: Baseline, 2 minute after bolus dose, at the beginning of fibre optic intubation, after advancing endotracheal tube through nasopharynx, 2 minute after nasotracheal intubation , 10 minute after nasotracheal intubation	—

Secondary

Measure	Time frame
1 .To assess & compare hemodynamic response (SBP, DBP, MAP, HR) to intubation.Timepoint: Baseline, 2 minute after bolus dose, at the beginning of fibre optic intubation, after advancing endotracheal tube through nasopharynx, 2 minute after nasotracheal intubation , 10 minute after nasotracheal intubation	—

Countries

India

Contacts

Public ContactDr Jain Prashant Abhay

SMS medical college

Drneelu13@gmail.com9782480455

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026