Study done to reduce time of orthodontic treatment by comparing two methods 1)injecting -Injectable platelet rich fibrin (IPRF- derived from patients own blood ) and by piezocision( type of minimally invasive procedure) and checking levels of bone marker parameters in gingival fluid .

Comparative evaluation of effect of IPRF and Piezocision on rate of orthodontic tooth movement and RANKL and OPG levels in GCF An in vivo study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073219

Enrollment

Registered

2024-09-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: IPRF -Injectable platelet rich fibrin.: Injection of IPRF On experimental site . Collection of GCF and measurement of tooth movement at -T0 baseline T1 after 2 weeks T2 after 4 weeks T3

Eligibility

Inclusion criteria

Inclusion criteria: Aged 18 years or above. - Patient requiring maxillary first Premolar extraction. - Angle’s class I/ class II molar relationship. - No history of orthodontic treatment. - No systemic disease. - No periodontal disease. - Good oral hygiene

Exclusion criteria

Exclusion criteria: -Patients with Systemic diseases -Patients taking medication that can interfere with orthodontic treatment. - Poor oral hygiene. -Periodontally compromised patients. -Patients with parafunctional habits -Angles’s class III molar relationship -Extraction other than first premolar extraction in the maxillary arch

Design outcomes

Primary

Measure	Time frame
GCF samples will be collected from buccal and distobuccal sides of canine of experimental side and the control side, in both, 1-PRF and piezocision group.Timepoint: baseline 2 weeks 4 weeks 6 weeks	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Ratika Sawhney

Inderprastha Dental College and Hospital

deepti.yadav@yahoo.com9212794482

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026