Active fluid in removal in patients with infection and organ failure

Active bundle De Resuscitation in Septic shock : A Randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/073205

Enrollment

150

Registered

2024-09-02

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R652- Severe sepsis

Interventions

Intervention1: ACTIVE DE RESUSCITATION GROUP: active de resuscitation under guidance of VExUS by administering furosemide infusion started with 10mg/hr , maximum dose of 250mg/day. fluid restriction,

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with septic shock resolution the lactate level less than 4 mmol/l and nor adrenaline dose less than 0.15microgram/kg/min. 2. Patients with cumulative positive fluid balance more than 2 litre and VExUS more than 1

Exclusion criteria

Exclusion criteria: 1.Patients age less than 18 years 2.Pregnancy and lactating women 3. CKD (chronic kidney disease) 4. CLD (chronic liver disease) 5.Solid organ and Hematopoietic stem cell transplant patients 6. Burn injury patients 7. Patient is on chronic dialysis 8. Anuric patient

Design outcomes

Primary

Measure	Time frame
Cumulative negative fluid balance at day 3 and VExUS less than 1Timepoint: 3 days	—

Secondary

Measure	Time frame
30 days mortalityTimepoint: day 30;acute kidney injury on day 3Timepoint: day 1 to 3;Need of Renal Replacement therapy on day 3Timepoint: day 1 to 3;vasopressor free daysTimepoint: day 1 to 30;ventilator free daysTimepoint: day 1 to 30	—

Countries

India

Contacts

Public ContactDr Rahul Kumar Anand

All India Institute of Medical Sciences, New Delhi

drrahulkanand@gmail.com9013082271

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026