Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Tablet Melatonin: Tablet melatonin 3 mg two tablets given orally with sips of water two hours before intubation
Control Intervention1: Tablet Pregabalin: Tablet pregabalin 75 mg two tab
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: 1. All Patients aged 18 years to 65 years 2. Patients with American Society of Anaesthesiologists (ASA) physical status I to II 3. Patients with Mallampati grade (MPG) I to II
Exclusion criteria
Exclusion criteria: 1. Patients with sleep disorders 2. Patients who are already on study drugs 3. Patients with known allergy to study drugs 4. BMI more than 30 kg/m2 5. Patients with anticipated difficult intubation 6. Duration of surgical procedure exceeding 4 hours 7. Pregnant and lactating women 8. Patients not willing to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study changes in hemodynamic parameters such as heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressureTimepoint: Before administering study drugs (T0), before induction of anaesthesia (T1), Just before intubation (T2), 1 minute(T3), 3 minutes(T4), 6 minutes (T5), 9 minutes (T6) and 15 minutes (T7) after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To study the induction dose of IV propofol between the two groups 2. Patient sedation scores using Observers assessment of Alertness/Sedation scores(OASS) 3. Intraoperative requirements of IV fentanylTimepoint: Sedation scores just before induction of general anaesthesia (S0), 15 minutes (S1), 30 minutes (S2), 60 minutes (S3) after extubation | — |
Countries
India
Contacts
Public ContactDr M Madhusudhan
Sri Venkateswara Institute of Medical Sciences
Outcome results
None listed