Health Condition 1: F320- Major depressive disorder, singleepisode, mild
Conditions
Interventions
Intervention1: Fluoxetine, Mirtazapine: Oral Fluoxetine 20mg once daily after lunch for a duration of 3 months
, Oral Mirtazapine 7.5mg once daily before bed for a duration of 3 months
Control Interve
Sponsors
Dr Asmita Pandey
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of Major Depression of at least 2 weeks duration. 2. Patients having mild to moderate depression as per ICD 10 criteria. 3. Patients between 18-45 years. 4. Patients who are willing to take part in the study with signed and written informed consent. 5. Patients can be both male and female. 6. Patients must be medically stable.
Exclusion criteria
Exclusion criteria: o Patients who are not willing to sign in after informed consent. o Pregnant, breast feeding, child bearing age using contraception. o Patient with severe depression o Patient with a K/C/O any Autoimmune conditions like SLE, Myasthenia gravis, Vitiligo, Psoriasis, Rheumatoid arthritis etc. o Patient receiving prior antidepressants within 3 months of enrollment. o Patient with a history of Bipolar disorder. o Patient with any hepatic and renal impairment. o Patient taking concomitant medications such as- NSAIDs and anticoagulants. o Patient with suicidal tendencies interfering with compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of the combination of oral fluoxetine with duloxetine versus oral fluoxetine with mirtazapine on patients of major depression the assessment will be done using Hamilton Depression Rating Scale Timepoint: Baseline 4 weeks 8 weeks 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To monitor the safety of the combination of oral fluoxetine and duloxetine versus oral fluoxetine and mirtazapine in terms of adverse drug events.Timepoint: 0,4,8 and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Asmita Pandey
Gajra Raja Medical College
Outcome results
None listed