Comparison of Simvastatin Enhanced Titanium prepared platelet rich fibrin Scaffold and Standard Titanium prepared platelet rich scaffold on Bone changes Around Implants

Efficacy of Titanium prepared Platelet rich fibrin(T-PRF) scaffold loaded with Simvastatin versus Titanium prepared Platelet rich fibrin(T-PRF) on peri implant bone changes a randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/073006

Enrollment

Registered

2024-08-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K069- Disorder of gingiva and edentulousalveolar ridge, unspecified

Interventions

Intervention1: Simvastatin loaded in Titanium prepared platelet rich fibrin: Titanium prepared platelet rich fibrin is loaded with simvastatin 1.2mg and placed in osteotomy site for implant placement

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients. Partially edentulous patient with missing posterior teeth.

Exclusion criteria

Exclusion criteria: Patients who are pregnant and lactating. Patients with history of bone metabolic disease. Patients currently taking drug that can influence bone metabolism. Use of bisphosphonates in last 4 years. Patients who are smokers.

Design outcomes

Primary

Measure	Time frame
Peri implant bone changesTimepoint: Day 0(The day of implant placement) and at 6 month	—

Secondary

Measure	Time frame
Mean crestal bone changes after implant loadingTimepoint: At 12th month	—

Countries

India

Contacts

Public ContactDR Uma S

Meenakshi Ammal Dental College and Hospital

rajaramvijayalakshmi@gmail.com9444765440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026