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PreOp 50 Percent Magnesium Sulphate VS 2 Percent Plain Lignocaine Nebulization For Prevention Of Post Intubation Sore Throat

A Comparison of Efficacy of Preoperative Nebulized Magnesium Sulphate (50 Percent) Versus Plain Lignocaine (2 Percent) For the Prevention of Postoperative Sore Throat in Patients Requiring Endotracheal Intubation - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/08/072943
Enrollment
62
Registered
2024-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N611- Abscess of the breast and nipple Health Condition 2: K810- Acute cholecystitis Health Condition 3: H700- Acute mastoiditis Health Condition 4: H605- Acute noninfective otitis externa Health Condition 5: H650- Acute serous otitis media Health Condition 6: J019- Acute sinusitis, unspecified Health Condition 7: J039- Acute tonsillitis, unspecified Health Condition 8: H721- Attic perforation of tympanic membrane Health Condition 9: K402- Bilateral inguinal hernia, withoutob

Interventions

Control Intervention1: Nebulized Magnesium Sulphate (50%): 0.5 ml of 250mg (50%) Nebulized Magnesium Sulphate + 3.5 ml Normal Saline will be given 20 minutes prior to induction of Anaesthesia for 15 m

Sponsors

GMERS Medical College Gandhinagar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I and II Mallampati Grade I and II Age :18-50 years Weight: 50-80 kg Both Male and Female Genders Patients undergoing surgery with duration ranging from 1-3 hrs under general anaesthesia with tracheal intubation

Exclusion criteria

Exclusion criteria: Patient refusal for Nebulization Patients undergoing Head and Neck Surgeries Patients with a history of preoperative sore throat or any respiratory disease Pregnant/Lactating females Patients allergic to the study drugs Patients with compromised renal function, cardiac diseases and neuromuscular disease. Patients with NasoGastric tube or any nasal or throat packs or who require these intraoperatively. Patients with anticipated difficult intubation. Patients requiring laryngoscopy and intubation for over 30 seconds or necessitating more than one attempt for intubation. Patients requiring the chronic use of steroids and/or the use of NSAIDS

Design outcomes

Primary

MeasureTime frame
To compare the incidence of Postoperative Sore Throat (POST) among patients receiving nebulized magnesium sulphate (50%) and those receiving nebulized plain lignocaine (2%) requiring endotracheal intubation.Timepoint: The incidence and severity of At 0 h (on arrival to post-anesthesia care unit (PACU)), 2, 4, 6, 8, 12 and 24 h postoperatively—

Secondary

MeasureTime frame
To observe the occurrence of any side effects Eg. Nausea/Vomiting, skin rash, dry mouth, hypotension, bradycardia and cough etc. Timepoint: in the first 24hrs post nebulization—

Countries

India

Contacts

Public ContactDr Shobhana Gupta

GMERS Medical College, Gandhinagar

hinagadani@gmail.com8690501339

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026