The effect of dexmedetomidine nebulisation on hemodynamic [heart rate] response to intubation skin incision and sternotomy in patients undergoing coronary artery bypass graft

The Effect of Dexmedetomidine Nebulisation on Hemodynamic Response to intubation,Skin Incision and Sternotomy in patients Undergoing Coronary Artery Bypass graft: A prospective Randomised Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072895

Enrollment

Registered

2024-08-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: - Health Condition 3: I257- Atherosclerosis of coronary arterybypass graft(s) and coronary artery of transplanted heart with angina pectoris

Interventions

Intervention1: Drug( dexmedetomidine) group : Nebulized dexmedetomidine group (D). Nebulisation with Dexmedetomidine 1 mcg/kg diluted to 4 ml with distilled water Control Intervention1: Saline group

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years 2. Both genders 3. Elective CABG with or without valve repair or replacement

Exclusion criteria

Exclusion criteria: 1. Anticipated difficult airway 2. Preoperative heart rate less than 50 beats per minute 3. Second degree heart block and bundle branch blocks 4. Uncontrolled atrial fibrillation and ventricular rate 5. Emergency surgery 6. Known allergy to the study drug 7. Autonomic dysfunction 8. Number of intubation attempts are more than 2.

Design outcomes

Primary

Measure	Time frame
To compare the effect of nebulized dexmedetomidine and placebo (sterile water) on change in Heart rate (HR) during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery.Timepoint: T1: prenubilization (Preoperative area), At the time of receiving the patient in pre op area before nebulization T2: 30 Mins during nebulization (before shiftingfrom preoperative area to operating room) T3: 1 min after intubation T4: 5 min after intubation T5: 10 min after intubation T6: 20 min after intubation T7: 1 min after skin incision T8: 1 min after completion of sternotomy. T9: 10 mins after completion of sternotomy.	—

Measure

Time frame

To compare the effect of nebulized dexmedetomidine and placebo (sterile water) on change in Heart rate (HR) during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery.Timepoint: T1: prenubilization (Preoperative area), At the time of receiving the patient in pre op area before nebulization T2: 30 Mins during nebulization (before shiftingfrom preoperative area to operating room) T3: 1 min after intubation T4: 5 min after intubation T5: 10 min after intubation T6: 20 min after intubation T7: 1 min after skin incision T8: 1 min after completion of sternotomy. T9: 10 mins after completion of sternotomy.

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Secondary

Measure	Time frame
1. Compare the effect of nebulized dexmedetomidine and placebo on change in systolic blood pressure , diastolic blood pressure , Mean arterial pressure during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 2. Compare the effect of nebulized dexmedetomidine and placebo on the dose of propofol required during intubation, skin incision and sternotomy during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 3. Compare the effect of nebulized dexmedetomidine and placebo on the Incidence of vasopressors requiredduring intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 4. Compare the effect of nebulized dexmedetomidine and placebo on the time to be awake after shifting to ICU in patients of coronary artery bypass graft surgery.Timepoint: T1: prenubilization , At the time of receiving the patient in pre op area before nebulization T2: 30 Mins T3: 1 min after intubation T4: 5 min after intubation T5: 10 min after intubation T6: 20 min after intubation T7: 1 min after skin incision T8: 1 min after completion of sternotomy. T9: 10 mins after completion of sternotomy.	—

Measure

Time frame

1. Compare the effect of nebulized dexmedetomidine and placebo on change in systolic blood pressure , diastolic blood pressure , Mean arterial pressure during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 2. Compare the effect of nebulized dexmedetomidine and placebo on the dose of propofol required during intubation, skin incision and sternotomy during intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 3. Compare the effect of nebulized dexmedetomidine and placebo on the Incidence of vasopressors requiredduring intubation, skin incision, and sternotomy intraoperatively in patients of coronary artery bypass graft surgery. 4. Compare the effect of nebulized dexmedetomidine and placebo on the time to be awake after shifting to ICU in patients of coronary artery bypass graft surgery.Timepoint: T1: prenubilization , At the time of receiving the patient in pre op area before nebulization T2: 30 Mins T3: 1 min after intubation T4: 5 min after intubation T5: 10 min after intubation T6: 20 min after intubation T7: 1 min after skin incision T8: 1 min after completion of sternotomy. T9: 10 mins after completion of sternotomy.

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Countries

India

Contacts

Public ContactDr Ajay Kumar

All India Institute of medical sciences Rishikesh

Ajay.anaes@aiimsrishikesh.edu.in9340482058

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026