Health Condition 1: K729- Hepatic failure, unspecified
Conditions
Interventions
Intervention1: GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF ) IN PATIENT WITH ACUTE ON CHRONIC LIVER FAILURE: PATIENTS ADMITTED IN THE DEPARTMENT OF HEPATOLOGY WITH DIAGNOSIS OF ACUTE ON CHRONIC LIVER
Sponsors
SCB MEDICAL COLLEGE
Eligibility
Inclusion criteria
Inclusion criteria: During the study period all consecutive patient diagnosed with ACLF will be enrolled in the study
Exclusion criteria
Exclusion criteria: Age younger than 12 years and older than 75 years Patients with HCC or portal vein thrombosis Patients in septic shock. Patients with TLC count more than 50000 Patients with HIV seropositivity Patient with significant co morbidity like uncontrolled diabetes CKD CVA Pregnancy Patient with known hypersensitivity to G-CSF Patients with mental illness and in alcohol withdrawal syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyse the survival benefit at day 60 in ACLF patients treated with G CSF.Timepoint: To analyse the survival benefit at day 60 in ACLF patients treated with G CSF. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate whether GCSF treatment results in any change in MELD and CTP score To investigate whether GCSF treatment results in prevention of new onset Hepatic encephalopathy and Hepatorenal syndrome. To investigate whether etiology of ACLF impacts response to GCSF treatment Timepoint: All secondary outcomes to be assessed at day 60 after completion of GCSF therapy | — |
Countries
India
Contacts
Public ContactDR ABHISHEK KUMAR
SCB MEDICAL COLLEGE CUTTACK ,ODISHA
Outcome results
None listed