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Study of Monocyte characteristics for early detection of infection in patients.

Monocyte Distribution Width (MDW) as a useful indicator for early screening of sepsis and efficacy in screening patients with positive blood culture: A Prospective Observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/08/072884
Enrollment
105
Registered
2024-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R798- Other specified abnormal findingsof blood chemistry

Interventions

None listed

Sponsors

RUBY HALL CLINIC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Admitted in ICU in Ruby Hall clinic with suspicion of sepsis as defined by sepsis 3 criteria 2. Those whose complete blood count, blood culture and other lab tests will be sent within 12hours of admission

Exclusion criteria

Exclusion criteria: 1. Patients with an inadequately low monocyte count (less than 100/µl) 2. Patients with a history of onco-haematological disease, immunocompromised, that could affect monocyte size and activation in response to infection. 3. Pregnant women 4. Patients admitted more than once to prevent duplication of data.

Design outcomes

Primary

MeasureTime frame
Patients will be grouped into blood culture positive and negative and Monocyte Distribution width, C-reactive protein (CRP), and Procalcitonin (PCT) value will be correlated with the blood culture and other cultures in all the groups.Timepoint: within 2years

Secondary

MeasureTime frame
-MDW efficacy in predicting sepsis in comparison to PCT and its variability in different group of patients.Timepoint: within 2 years;-Using MDW as prognostication marker to see the length of ICU stay.Timepoint: within 2years;A follow-up of MDW, PCT, and CRP will be performed later in the course of sepsis among survivors and non-survivors to assess the prognostic value.Timepoint: within 2 years;Patient with above parameters like MDW, PCT, CRP and Neutrophil: lymphocyte ratio value will be correlated for each group and the significance of MDW in predicting sepsis.Timepoint: within 2years

Countries

India

Contacts

Public ContactDr Priyanka mohapatra

Ruby Hall Clinic Pune

dr.sanmay@gmail.com9822058461

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026