None listed
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Medical Research Council UK
Eligibility
Inclusion criteria
Inclusion criteria: 1.Male or Female who participated in the previous study (Project No.3114) 2.Age: 20-70 (at the time of the enrolment of Project no.3114)
Exclusion criteria
Exclusion criteria: 1. Unwilling to participate 2. Has a history of cough, cold, and fever 3. Unable to lie still 4. Unable to hold breath voluntarily or hear instructions 5. Unable to complete the process because of physical disabilities. 6. Pregnant women /lactating women 7. Had surgery in the last 6 weeks 8. Had a scan or x-ray in the last 2 weeks which involved taking a contrast medium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre-study power calculations to detect cis and trans mQTLs in 13,278 participants showed that we will have 80% power to detect a cis mQTL at a p-val threshold of 1e-8 with rsq is equal to 0.003. We have included a robust and reproducible federated analysis approach. We will develop a github pipeline where collaborators will download a suite of scripts and run the analyses in their cohort. 1.mQTL analyses 2.EWAS analyses 3.Replication 4.MR analysesTimepoint: Total 1 year of the project, consist of 6 months of laboratory execution and 6 months of data analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| NATimepoint: NA | — |
Countries
India
Contacts
Public ContactDr Sharayu Mhatre
Centre for Cancer Epidemiology, Tata Memorial Centre
Outcome results
None listed