To compare the duration of postoperative analgesia in patients undergoing Laparoscopic cholecystectomy using Magnesium sulphate and Clonidine as adjuvants to Bupivacaine in Transversus Abdominis Plane block.

Comparison of Magnesium sulphate and Clonidine as adjuvant to Bupivacaine in ultrasound guided subcostal Transversus Abdominis Plane block for postoperative analgesia in patients undergoing Laparoscopic cholecystectomy. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072839

Enrollment

Registered

2024-08-21

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ultrasound guided subcostal transversus abdominis plane block: Total 15 ml drug volume consisting of 0.25% bupivacaine + 100 mg magnesium sulphate bilaterally on each side Control Inter

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years, either gender, belonging to ASA (American Society of Anaesthesiologists) grade I or grade II undergoing laparoscopic cholecystectomy with duration of surgery not exceeding 120 minutes.

Exclusion criteria

Exclusion criteria: 1. Patients allergic to the drugs being used in the study. 2. Infection or inflammation at the site of block application. 3. Patients who have cognitive disability and unable to understand the VAS score.

Design outcomes

Primary

Measure	Time frame
To compare the duration of postoperative analgesia (time to first rescue analgesia as per VAS score) using magnesium sulphate and clonidine as adjuvants to bupivacaine in ultrasound guided transversus abdominis plane block in patients undergoing laparoscopic cholecystectomyTimepoint: postoperatively at 0 hour, 1 hour, 2 hour, 4 hour, 8 hour and 24 hours.	—

Secondary

Measure	Time frame
1. Total analgesic requirement in 24 hours. 2. To study hemodynamic changes (blood pressure and heart rate) intraoperatively and postoperativelyTimepoint: Intraoperatively and postoperatively	—

Countries

India

Contacts

Public ContactDr Sujata Chaudhary

Vardhman Mahavir Medical College and Safdarjung hospital

sujatac462@gmail.com9999051546

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026