Health Condition 1: D759- Disease of blood and blood-formingorgans, unspecified
Conditions
Interventions
Intervention1: Hydroxyurea medicine and standard treatment: The intervention group will receive the current standard treatment and hydroxyurea medicine. Hydroxyurea will be started as per the national
Sponsors
SEWA Rural
Eligibility
Inclusion criteria
Inclusion criteria: All consenting pregnant women with sickle cell disease seeking outpatient or inpatient care at Kasturba Maternity Hospital or its satellite center during the second trimester of pregnancy will be eligible for enrolment. Sickle cell disease status will be confirmed by a gold standard laboratory test- HPLC.
Exclusion criteria
Exclusion criteria: Dont, provide consent, out of study area, already on hydroxyurea treatment, not intended to get services at SEWA Rural, and those who have already the presence of contra indication to hydroxyurea medicine at baseline which includes neutropenia, thrombocytopenia, abnormal increase in serum creatinine, or hepatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Adverse maternal outcome event score per person month will be primary outcome. 2.Time to first time occurrence of severe maternal adverse event since last menstruation period.Timepoint: The outcome will be assessed at interim midline (at one year) and endline (at two years). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be event rates per 100 person months for each of adverse maternal outcomes & foetal outcomes.Timepoint: The outcome will be assessed at interim midline (at one year) & at endline (at two years). | — |
Countries
India
Contacts
Public ContactShrey Desai
SEWA Rural
Outcome results
None listed