Clinical trial of comparison between dexmedetomidine and magnesium sulphate given by nebulisation to patients in reducing body response following larygoscopy and intubation response.

COMPARATIVE EVALUATION OF NEBULISED DEXMEDETOMIDINE AND NEBULISED MAGNESIUM SULPHATE ON ATTENUATION OF PRESSOR RESPONSE FOLLOWING LARYNGOSCOPY AND INTUBATION - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/08/072702

Enrollment

Registered

2024-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulisation with dexmedetomidine: Dexmedetonidine is an alpha 2 agonist which provides sedation, sympatholysis, analgesia, opioid and anaesthetic sparing effect.Trial to assess the att

Eligibility

Inclusion criteria

Inclusion criteria: Patient weighing between 50-80 kilograms. Patients belonging to ASA Grade I and Grade II. Patients undergoing elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients of uncontrolled hypertension, ischemic heart disease, AV blocks, arrhythmoas, ventricular dysfunction. Patients wuth hepatic and renal dysfunction. Patients of anticipated difficult airway. Patients allergic to the stidy drug. Patient unwilling to participate in the study.

Design outcomes

Primary

Measure	Time frame
To compare the hemodynamic paramater- Heart rate, following intubation in either groupsTimepoint: 10 mins post intubation	—

Secondary

Measure	Time frame
To compare other hemodynamic paramters - Systolic blood pressure, Diastolic blood pressure and mean arterial pressure in either groups.Timepoint: 10 mins post intubation;To compare postoperative sedation in either groupTimepoint: Within one hour in recovery room;To compare the occurrence and severity of postoperative sore throat in either group.Timepoint: Within one hour in recovery area;To compare the total dose of propofol required for intubation in either group.Timepoint: 2-3 mins before intubation	—

Measure

Time frame

To compare other hemodynamic paramters - Systolic blood pressure, Diastolic blood pressure and mean arterial pressure in either groups.Timepoint: 10 mins post intubation;To compare postoperative sedation in either groupTimepoint: Within one hour in recovery room;To compare the occurrence and severity of postoperative sore throat in either group.Timepoint: Within one hour in recovery area;To compare the total dose of propofol required for intubation in either group.Timepoint: 2-3 mins before intubation

—

Countries

India

Contacts

Public ContactDr Megha Aggarwal

Hindu Rao Hospital and North DMC medical college

Megha91082@yahoo.com7982024475

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026